TMD (Tuned Mass Damper) is fit for the vibration control of a spatial structure because it is possible to install the TMDs by a single supporting point. Therefore, there are many studies on the vibration control for a spatial structure by TMDs. In previous studies, analytical investigations have been conducted ambitiously. However, no studies have been conducted with TMDs installed in full-scale buildings. In this study, the response reduction effect of double TMDs on the roof surface of the target structure is investigated by large shaking table tests on a 1/4-scale model of a gymnasium.