The built-up H-shaped steel member is fabricated from three steel plates: two flanges and one web. Different steel grades may be used for the flanges and the web to fulfill design requirements. This study focuses on built-up steel members with a large width-to-thickness ratio and different tensile strengths at the flanges and the web. To clarify their tensile strength and deformation capacity, full-scale tensile tests and numerical analyses were conducted. Furthermore, a design method for evaluating yield tensile stress and yield strain of built-up H-shaped steel members with different flange and web strengths was proposed.