The objective of this paper is to verify the effectiveness of Topology optimization for Lattice shell structures using CONLIN method. Firstly, using a basic example, we compare the stiffness with the solution obtained by ESO method and we examine their effectiveness. Next, CONLIN method is used to perform topology optimization for Partial multi-layered lattice shell structures and single-layer lattice shell structures. The stiffness of the optimized structures is compared, and the effectiveness of CONLIN method in generating lattice shell structures that are both safe and economically superior is examined.