This article evaluates the optimal placement of AEDs in large-scale urban facilities with skyscrapers using Golden Hour Principle. According to the results, the placement of AEDs differs significantly when the metric of maximizing smallest survival rate is used compared with maximizing average survival rate. For maximizing the average survival rate, it is better to install AEDs on a floor slightly below the top floor rather than on the top floor in the case of skyscrapers. However, if the goal is to maximize the smallest survival rate, then installing AEDs on the most disadvantageous top floor is the optimal configuration.