抄録
By complete reading of the genome sequence, in the near future we will be able to determine the role of genomic DNA sequence variation among individuals, such a single nucleotide polymorphism (SNP), in the pathogenesis of diseases and responses to drugs. Comprehension of the genome will also accelerate understanding of the transcriptome, the whole transcripts present in a cell. Messages induced by a new therapy, such as an unexpected adverse effects, will not be missed by using such a comprehensive assay. Allergic diseases will be classified into subtypes depending on the impaired or affected molecule. Herein, I introduce our research strategy for genome-wide analysis of SNP related to asthma, granted by the Millennium Genome Project of the Japanese Government, and review the recent results of transcriptome analysis using microarray technology.
