Allergology International
Online ISSN : 1440-1592
Print ISSN : 1323-8930
ISSN-L : 1323-8930
Original Articles
Early introduction of very small amounts of multiple foods to infants: A randomized trial
Tatsuo NishimuraMitsuru FukazawaKeisuke FukuokaTeruo OkasoraShinichi YamadaShigeharu KyoMakoto HomanTakuma MiuraYasuyuki NomuraShinya TsuchidaShigehiro YajimaSatoshi AokiYutaka NakamuraTaisuke HosakaHirokazu HidakaHiroyuki YamamoriAkira InoueJiro Morimoto
ジャーナル フリー

2022 年 71 巻 3 号 p. 345-353


Background: We investigated whether multiple food allergies could be safely prevented by simultaneously administering very small amounts of multiple foods.

Methods: Infants 3-4 months old with atopic dermatitis from 14 primary care pediatric clinics in Japan were enrolled in this randomized, placebo-controlled trial. The infants were administered either mixed allergenic food powder (MP) containing egg, milk, wheat, soybean, buckwheat, and peanuts, or placebo powder (PP). The amount of powder was increased in a stepwise manner on weeks 2 and 4, and continued until week 12. The occurrence of food allergy episodes after powder intervention was assessed at 18 months old. This trial was registered with the University Hospital Medical Information Network Clinical Trials Registry (number UMIN000027837).

Results: A total of 163 participants were randomly allocated to either the MP group (n = 83) or the PP group (n = 80). The incidence of food allergy episodes by 18 months was significantly different between the MP and PP groups (7/83 vs. 19/80, respectively; risk ratio 0.301 [95% CI 0.116-0.784]; P = 0.0066). Egg allergies were reduced in the MP group. In addition, food allergy episodes from any of the other five foods were significantly reduced, although the reductions in those due to individual foods were not significant.

Conclusions: Gradually increasing the intake of very small amounts of multiple foods in early infancy can safely reduce the incidence of egg allergies. Other foods may also suppress food allergies, but no definitive conclusions could be reached.



© 2022 by Japanese Society of Allergology
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