Fluorescence Molecular Sensing for Endocrine-disrupting Chemicals and Their Analogues Based on Dansyl or Anthranilate Modified β- and γ-Cyclodextrins

抄録

A fluorescent chemo-sensor for endocrine-disrupting chemicals has been studied by investigating fluorescence spectral changes with and without a guest molecule of regio-selective bis dansylglycine or anthranilate modified β-and γ-cyclodextrins. These host compounds show an increasing or decreasing pure monomer fluorescence intensity upon the addition of such guests as dioxin analogues, p-nonylphenol, 2,4-dichlorophenoxyacetic acid, bisphenol A, and diethyl phthalate. The extent of the fluorescence variations with the guest is used to display the sensing factors, ΔI/I₀, of these host molecules, where I and I₀ are the fluorescence intensities in the presence and absence of a guest and ΔI is I-I₀. These hosts exhibit various values of ΔI/I₀, which indicates the possibility of pattern recognition for endocrine-disrupting chemicals. These guests are detected with a remarkable response range by these hosts.