Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Notes
Novel Observation of a Circular Dichroism Band Originating from Amyloid Fibril
Hiroshi ABEHiroshi NAKANISHI
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2003 年 19 巻 1 号 p. 171-173

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A peptide fragment of a non-amyloid-β component (NAC(1-13)) was studied by CD and electron microscopy. Typical amyloid fibrils were observed by EM in a solution of NAC(1-13). In addition to the β-structural CD band in the far-UV region, a novel CD band near 285 nm was observed in a peptide solution of NAC(1-13). Taking the NAC(1-13) to contain neither an aromatic amino acid residue nor cystine into account, the CD band can be attributed to amyloid fibrils of NAC(1-13).
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© 2003 by The Japan Society for Analytical Chemistry
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