Notes
Determination of Repaglinide in Pharmaceutical Formulations by HPLC with UV Detection
2003 年 19 巻 12 号 p. 1675-1677
詳細
2003 年 19 巻 12 号 p. 1675-1677
A simple, precise and rapid RP-HPLC method was developed for the determination of repaglinide in pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of methanol: 0.1% v/v triethylamine (pH adjusted to 7 with orthophosphoric acid) and detection was done at 235 nm using nimesulide as internal standard. The linearity range was 0.1 to 0.5 μg/ml. The intra-day and inter-day precision were in the range of 0.48 to 1.01 and 0.15 to 1.15, respectively.
