Crystal Structure of 3,3-Dichloro-N-p-methoxyphenyl-4-(2-phenylstryl)-2-azetidinone

抄録

3,3-Dichloro-N-p-methoxyphenyl-4-(2-phenylstryl)-2-azetidinone (C₂₂H₁₅Cl₂NO₂) was studied by X-Ray analysis, which indicated a monoclinic space group, P2₁/c, with a = 9.619(5), b = 13.879(4), c = 14.161(5)Å, β = 100.16(3)°, V = 1860.8(13)ų, Z = 4, D_c = 1.414 g cm^-3, μ(Mo K_α) = 0.366 mm^-1 and F₀₀₀ = 816. The structure was solved by direct methods and refined to R = 0.041 for 4026 reflections [I > 2σ(I). The β-lactam ring (2-azetidinone) has antimicrobial affects. The substituents of the methoxyphenyl and phenyl substituents do not change the activity property of the beta-lactam ring, and the activity properties depend on the planarity of the β-lactam ring.