Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
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Preparation of a Novel Iodide-Selective Electrode Based on Iodide-Miconazole Ion-Pair and Its Application to Pharmaceutical Analysis
Fahimeh JALALIMohammad J. RAJABIGholamreza BAHRAMIMojtaba SHAMSIPUR
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2005 Volume 21 Issue 12 Pages 1533-1535

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Abstract

An iodide-miconazole ion-paired complex was used as a suitable ion-exchanger for the preparation of a plasticized-PVC membrane electrode. Among different solvent mediators tested, dioctylsebacate exhibited the proper response characteristics, including Nernstian slope of the calibration curve, fast response time and good reproducibility of the emf values. The electrode exhibits a Nernstian slope of -59.8 ± 0.5 mV decade-1 for I- ion over a concentration range of 1.0 × 10-5 - 1.0 × 10-2 M with a limit of detection of 7.0 × 10-6 M. The electrode displays a good selectivity for I- with respect to a number of inorganic and organic species. It can be used over a pH range of 2.5 - 8.5. The membrane sensor was successfully applied to the determination of iodide in water samples and blood serum, as well as in pharmaceutical products such as iodoquinol and thyroxin.

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© 2005 by The Japan Society for Analytical Chemistry
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