Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Original Papers
Suppression of Matrix-related Ions Using Cyclodextrin in MALDI Mass Spectrometry
Sohta YAMAGUCHITakashi FUJITATatsuya FUJINOTakashi KORENAGA
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JOURNALS FREE ACCESS

2008 Volume 24 Issue 11 Pages 1497-1500

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Abstract

An effective technique for the suppression of matrix-related ions in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry have been developed. Using typical organic matrices such as THAP (2,4,6-trihydroxyacetophenone) and CHCA (α-cyano-4-hydroxycinnamic acid) in a cyclodextrin cavity, we successfully measured the mass peaks of only protonated matrix ions and significantly suppressed their intensities and fragmentation. In addition, it became possible to analyze the mass peak of the analyte molecules (substance P and adenosine) without any interference from the matrix. We believe that this technique could be a powerful tool for MALDI mass spectrometry, particularly for low-molecular-weight compounds.

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© 2008 by The Japan Society for Analytical Chemistry
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