Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

Hiroshi NONAKA; Qi AN; Fuminori SUGIHARA; Tomohiro DOURA; Akira TSUCHIYA; Yoshichika YOSHIOKA; Shinsuke SANDO

doi:10.2116/analsci.31.331

Notes

Phenylboronic Acid-based ¹⁹F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

Hiroshi NONAKA, Qi AN, Fuminori SUGIHARA, Tomohiro DOURA, Akira TSUCHIYA, Yoshichika YOSHIOKA, Shinsuke SANDO

著者情報

キーワード: ¹⁹F NMR, ¹⁹F MRI, imaging, molecular probe, H₂O₂

ジャーナルフリー
電子付録

2015 年 31 巻 4 号 p. 331-335

DOI https://doi.org/10.2116/analsci.31.331

詳細

抄録

Herein, we report on a new ¹⁹F MRI probe for the detection and imaging of H₂O₂. Our designed 2-fluorophenylboronic acid-based ¹⁹F probe promptly reacted with H₂O₂ to produce 2-fluorophenol via boronic acid oxidation. The accompanying ¹⁹F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H₂O₂ by ¹⁹F chemical-shift-selective MRI.

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