An Extended-gate Type Organic FET Based Biosensor for Detecting Biogenic Amines in Aqueous Solution

Tsuyoshi MINAMI; Tsubasa SATO; Tsukuru MINAMIKI; Shizuo TOKITO

doi:10.2116/analsci.31.721

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An Extended-gate Type Organic FET Based Biosensor for Detecting Biogenic Amines in Aqueous Solution

Tsuyoshi MINAMI, Tsubasa SATO, Tsukuru MINAMIKI, Shizuo TOKITO

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Keywords: Organic field-effect transistor, histamine, putrescine, osmium polymer, horseradish peroxidase, diamine oxidase

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Supplementary material

2015 Volume 31 Issue 7 Pages 721-724

DOI https://doi.org/10.2116/analsci.31.721

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Abstract

This study is the first to report on the detection of biogenic amines in an aqueous solution using an organic field-effect transistor (OFET) device with an extended gate electrode modified with a layer of diamine oxidase and a horseradish peroxidase osmium-redox polymer. The limit of detection (LOD) for histamine was estimated to be 1.2 μM. These results reveal that extended-gate type OFET devices are highly suitable enzyme-based biosensors for the detection of biogenic amine levels.

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