Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
Original Papers
Facile Preparation of Photoactivatable Surfaces with Tuned Substrate Adhesiveness
Yoshihisa SHIMIZUMasao KAMIMURAShota YAMAMOTOShimaa A. ABDELLATEFKazuo YAMAGUCHIJun NAKANISHI
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2016 年 32 巻 11 号 p. 1183-1188

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This paper describes a facile method for the preparation of photoactivatable substrates with tuned surface density of an extracellular matrix peptide to resolve the impacts of biochemical and mechanical cues on collective cell migration. The controllability of surface ligand density was validated by cell adhesion and migration tests, complemented with fluorescence observation of an alternative ligand. Depending on the surface ligand density, HeLa cells either kept or lost collective characteristics. The present materials will be useful to address mechanobiology of collective cell migration.

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© 2016 by The Japan Society for Analytical Chemistry
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