A Reactive Oxygen/Nitrogen Species Sensor Fabricated from an Electrode Modified with a Polymerized Iron Porphyrin and a Polymer Electrolyte Membrane

Ryo MATSUOKA; Chihiro KOBAYASHI; Atsushi NAKAGAWA; Shigeo AOYAGI; Tatsuo AIKAWA; Takeshi KONDO; Shigenobu KASAI; Makoto YUASA

doi:10.2116/analsci.33.911

Original Papers

A Reactive Oxygen/Nitrogen Species Sensor Fabricated from an Electrode Modified with a Polymerized Iron Porphyrin and a Polymer Electrolyte Membrane

Ryo MATSUOKA, Chihiro KOBAYASHI, Atsushi NAKAGAWA, Shigeo AOYAGI, Tatsuo AIKAWA, Takeshi KONDO, Shigenobu KASAI, Makoto YUASA

Author information

Ryo MATSUOKA
HOKUTO DENKO CORPORATION
Chihiro KOBAYASHI
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Atsushi NAKAGAWA
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Shigeo AOYAGI
HOKUTO DENKO CORPORATION
Tatsuo AIKAWA
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Takeshi KONDO
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Research Institute for Science and Technology, Tokyo University of Science
Shigenobu KASAI
Graduate Department of Environmental Information Engineering, Tohoku Institute of Technology
Biomedical Engineering Research Center, Tohoku Institute of Technology
Makoto YUASA
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Research Institute for Science and Technology, Tokyo University of Science

Keywords: Anion radicals (O₂^−•), nitric oxide (NO), sensor, porphyrin, reactive oxygen species, reactive nitrogen species, modified electrode, electrochemical

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Supplementary material

2017 Volume 33 Issue 8 Pages 911-915

DOI https://doi.org/10.2116/analsci.33.911

Details

Abstract

We have developed an electrochemical reactive oxygen/nitrogen species sensor that can detect superoxide anion radicals (O₂^−•) and nitric oxide (NO). The reactive oxygen/nitrogen species sensor was fabricated by surface modification of an electrode with polymerized iron tetrakis(3-thienyl)porphyrin (FeT3ThP), and it can detect either O₂^−• or NO by switching the applied potential. Furthermore, we fabricated a sensor with improved selectivity by coating a Nafion^® film onto the poly(FeT3ThP)-modified electrode. An interference current caused by NO₂⁻ was seen for the poly(FeT3ThP)-modified electrode, while the interference current was significantly reduced at the Nafion^®/poly(FeT3ThP)-modified electrode, leading to improved selectivity for NO detection. The current response at the Nafion^®/poly(FeT3ThP)-modified electrode exhibited good linearity in the O₂^−• and NO concentration ranges 1.3 – 4.1, and 0.5 – 10 μM, respectively. The Nafion^®/poly(FeT3ThP)-modified and poly(FeT3ThP)-modified electrodes are highly versatile, because these electrodes can detect either O₂^−• or NO by switching the applied potential. Since the Nafion^®/poly(FeT3ThP)-modified and poly(FeT3ThP)-modified electrodes contain no bio-derived compounds, the reactive oxygen/nitrogen species sensor should be safe even when it is used in vivo.

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