Indirect Interactions between Raman Probes Encapsulated within Cucurbit[7]urils and Gold Nanorods to Enhance Long-term Stability and Signal

Abstract

Surface-enhanced Raman scattering (SERS) is a powerful technique that enhances Raman signals by adsorbing probe molecules on rough metal surfaces. However, SERS is limited because target molecules must strongly interact with metal to enhance a stable Raman signal. In this study, to improve long-term SERS stability, we use cucurbit[7]urils (CB[7]) as bridge molecules and sample containers to probe Rhodamine 6G (R6G) molecules. We observed interactions between gold nanorods (AuNRs) and CB[7] via aggregate formation, which enhanced the Raman signal and improved long-term R6G probe stability by up to 20 days when encapsulated within CB[7] during SERS analysis.