Analytical Sciences
Online ISSN : 1348-2246
Print ISSN : 0910-6340
ISSN-L : 0910-6340
Reviews
Analysis Method of the Ion Current–Time Waveform Obtained from Low Aspect Ratio Solid-state Nanopores
Masateru TANIGUCHI
Author information
JOURNALS FREE ACCESS

2020 Volume 36 Issue 2 Pages 161-175

Details
Abstract

Low aspect ratio nanopores are expected to be applied to the detection of viruses and bacteria because of their high spatial resolution. Multiphysics simulations have revealed that the ion current–time waveform obtained from low aspect ratio nanopores contains information on not only the volume of viruses and bacteria, but also the structure, surface charge, and flow dynamics. Analysis using machine learning extracts information about these analytes from the ion current–time waveform. The combination of low aspect ratio nanopores, multiphysics simulation, and machine learning has made it possible to distinguish different types of viruses and bacteria with high accuracy.

Fullsize Image
Information related to the author
© 2020 by The Japan Society for Analytical Chemistry
Previous article Next article
feedback
Top