Abstract
Four heptakis(6-O-alkyldimethylsilyl-2, 3-di-O-ethyl)-β-cyclodextrin (CD) having 6-O-alkyl groups of different chain length, heptakis(6-O-trimethylsilyl-2, 3-di-O-ethyl)-β-CD (MTDE-β-CD), heptakis(6-O-ethyldimethylsilyl-2, 3-di-O-ethyl)-β-CD (ETDE-β-CD), heptakis(6-O-octyldimethylsilyl-2, 3-di-O-ethyl)-β-CD (OTDE-β-CD) and heptakis(6-O-octadecyldimethylsilyl-2, 3-di-O-ethyl)-β-CD (ODDE-β-CD), were prepared and effect of the chain length of the 6-O-alkyl moiety on the enantioselectivity of the CD derivatives as chiral stationary phases were compared by measuring separation factors of a range of chiral test compounds in capillary gas chromatography. Enantioselectivity of the CD derivatives was observed to be in the order, ETDE-β-CD_??_MTDE-β-CD>OTDE-β-CD>ODDE-β-CD.
