Optimal Peak Separation Derived from Information Theory of Chromatography

Abstract

The optimal separation of peaks in column chromatography is derived from information theory based on FUMI. The optimal is shown to be described by the chromatographic resolution R_s. The information theory of column chromatography demonstrates that optimization based on FUMI can entail optimization on R_s as a special case. The peak capacity can also be derived theoretically from FUMI.