The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
NEW ANTIVIRAL ANTIBIOTICS; XANTHOCILLIN X MONO- AND DIMETHYLETHER, AND METHOXY- XANTHOCILLIN X DIMETHYLETHER. I
ISOLATION AND CHARACTERIZATION
AKIRA TAKATSUKISEIKICHI SUZUKIKUNIO ANDOGAKUZO TAMURAKEI ARIMA
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1968 Volume 21 Issue 12 Pages 671-675

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Abstract
The production, isolation, chemical and physical characteristics and biological properties of the new antiviral antibiotics, xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether are described. They were produced by two strains of Aspergillus sp. isolated from soil samples. The active principles were extracted from the mycelium, and isolated as yellowish crystals. They were identified as derivatives of xanthocillin X by physical methods. All three were effective against Newcastle disease, vaccinia and herpes simplex viruses in plate assays, and all inhibited the growth of Bacillus subtilis.
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© Japan Antibiotics Research Association
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