Abstract
Effects of XME, XDE and XTE (xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether) on multiplication of Newcastle disease virus (NDV) and on proliferation of chick embryo fibroblast cells (CEF) were examined. At low multiplicity, XME, XDE and XTE suppressed CPE at low concentrations. At high multiplicity, XME (10 mcg/ml) completely inhibited occurrence of CPE and syntheses of HA and infective virus, and at lower concentrations there was no difference in final yields of HA at 23 hours post infection, but a concentration dependency was found in synthesis of HA and suppression of CPE. XDE and XTE, on the other hand, did not inhibit HA synthesis completely at high concentration, but delayed the onset of HA production and partially arrested the occurrence of CPE post infection. All three antibiotics had very low toxicity against both grown and growing primary CEF. They also had no effect on free NDV particle and on viral adsorption onto CEF.
