STUDIES ON TUBERACTINOMYCIN (TUBERACTIN), A NEW ANTIBIOTIC. I

TAXONOMY OF PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION

Abstract

A new antibiotic, tuberactinomycin, has been isolated from fermentation broth of a streptomyces named Streptomyces griseoverticillatus var. tubei'acticus.Tuberactinomycin is a water-soluble antibiotic belonging to the basic peptide antibiotic group, and markedly stable in acid or neutral solution. Tuberactinomycin is recovered from fermentation broth by means of a cation exchange resin process. Tuberactinomycin shows low toxicity and the activity against pathogenic tubercular bacilli both in vitro and in vivo. Taxonomical study of the producing strain, the isolation and properties of the antibiotic are reported in this paper.