The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON BIOSYNTHESIS OF KASUGAMYCIN. III
BIOSYNTHESIS OF THE D-INOSITOL MOIETY
YASUO FUKAGAWATSUTOMU SAWATOMIO TAKEUCHIHAMAO UMEZAWA
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1968 年 21 巻 3 号 p. 185-188

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The incorporation of various 14C-labeled compounds into the D-inositol moiety was studied. Among U-14C-maltose, U-14C-glucose, U-14C-mannose, 1-14C-glycerol, U-14C-pyruvate, 1-14C-acetate, U-14C-myoinositol, 1-14C-glycine, 2-14C-glycine and 14C-D-inositol, only U-14C-myoinositol was incorporated at a high rate. From the dilution test of D-inositol, D-inositol was proved not to be a precursor of the D-inositol moiety of kasugamycin. The radiogaschromatography of 14C-kasugamycin showed the conversion of U-14C-myoinositol to the 14C-D-inositol moiety of kasugamycin.
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© Japan Antibiotics Research Association
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