ASCOCHLORIN, A NEW ANTIBIOTIC, FOUND BY PAPER-DISC AGAR-DIFFUSION METHOD. I

ISOLATION, BIOLOGICAL AND CHEMICAL PROPERTIES OF ASCOCHLORIN (STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. I)

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A new antibiotic, ascochlorin, C₂₃H₂₉O₄Cl, was obtained from the filter cake of the fermented broth of Ascochyta _viciae LIBERT. Ascochlorin inhibits plaque formation of both DNA and RNA viruses in the agar-diffusion plaque inhibition method. However, it showed no antiviral activity by the tube culture method. It showed cytotoxicity to chick embryo fibroblast monolayer and HeLa cells at a concentration of 0.3 meg/ml in tube culture. The anti biotic was obtained in two forms, the physical and chemical properties of which are described.