STUDIES ON T-2636 ANTIBIOTICS. III

A NEW COMPONENT, T-2636 F

抄録

A new antibiotic T-2636 F was isolated from three different sources, 1) the reaction mixture of T-2636 D with the esterase of Streptomyces rochei var. volubilis (No. T-2636), 2) the filtered broth of the Streptomyces strain, and 3) the bile and urine samples of rabbits, which was pre-administered T-2636 C parenterally. T-2636 F has the following chemical properties : colorless needles, m.p. 178-179°C(decomp.), i_max 228 mju (EtOH), [α]²⁴_D -210° (c 1.0, DMF), molecular formula C₂₅H₃₅NO₇-CH₃OH. T-2636 F shows moderate activities against Gram-positive bacteria. The preparation of the enzyme of Streptomyces and application of the enzyme for bioassay of T-2636 antibiotics are described.