The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STABILITY STUDIES WITH AMPHOTERICIN B AND AMPHOTERICIN B METHYL ESTER
D. P. BONNERW. MECHLINSKIC. P. SCHAFFNER
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1975 Volume 28 Issue 2 Pages 132-135

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Abstract

In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methyl ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5°C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.

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