BIOTRANSFORMATION, A NEW APPROACH TO AMINOGLYCOSIDE BIOSYNTHESIS: II GENTAMICIN
1976 年 29 巻 2 号 p. 140-146
詳細
1976 年 29 巻 2 号 p. 140-146
Utilizing a paromamine-producing mutant of Micromonospora purpurea blocked in the production of gentamicin, bioconversion of various minor gentamicin components into the gentamicin C complex was demonstrated. The compounds tested Were structurally related to the gentamicin C's and are found as minor components in the gentamicin fermentation. Based upon the bioconversions detected, a branched pathway for the biosynthesis of the gentamicin C components is proposed.
