RIBOSTAMYCIN PRODUCTION BY A MUTANT OF BUTIROSIN PRODUCING BACTERIA
1978 年 31 巻 10 号 p. 966-969
詳細
1978 年 31 巻 10 号 p. 966-969
By the use of our improved colony selection technique, xylostasin and ribostamycin producing mutants were isolated from nitrosoguanidine treated Bacillus circulars B15M, a producer of butirosins A and B. Among these structurally related aminoglycosides, ribostamycin is the well-known product of a Streptomyces and has not been isolated as a bacterial metabolite.
A selected mutant of strain 306, which produces xylostasin and ribostamycin, was further mutagenized in expectation of getting an improved strain having the ability to accumulate a large amount of ribostamycin in the culture broth. One mutant, strain 451, derived from strain 306, produced ribostamycin free of xylostasin.
