EFFECT OF DEMYCAROSYLTURIMYCIN ON RIBOSOMAL PEPTIDYLTRANSFERASE FROM ESCHERICHIA COLI
1978 年 31 巻 6 号 p. 610-615
詳細
1978 年 31 巻 6 号 p. 610-615
The effect of demycarosylturimycin H on bacterial growth, polypeptide synthesis and peptidyltransferase was studied. The effects are compared with those of intact turimycins acylated or deacylated in 4''-position of mycarose. The removal of the acyl group in 4''- position of mycarose leads to a total loss of inhibition of acceptor substrate binding while the removal of acyl mycarose moiety changes the pattern of inhibition of polypeptide synthesis.
