PIPERACILLIN (T-1220), A NEW SEMISYNTHETIC PENICILLIN. II
IN VITRO ANTIMICROBIAL ACTIVITY AND SYNERGY COMPARISON WITH CARBENICILLIN AND GENTAMICIN
1979 年 32 巻 1 号 p. 29-35
詳細
1979 年 32 巻 1 号 p. 29-35
Piperacillin, a new semisynthetic penicillin, was found to have potent antimicrobial activity against nearly all (405) tested bacterial species. Piperacillin was consistently 4-16-fold more active than carbenicillin against the Enterobacteriaceae, 16-32-fold against Pseudomonas acruginosa and Pseudomonas species, and 16-fold against Streptococcus faecalis. Carbenicillin and piperacillin were equally effective against Staphylococcus aureus, but inactivated by beta-lactamase. A 38% overall synergy rate for the piperacillin-gentamicin combination was identified, a finding similar to that for carbenicillin-gentamicin. Highest incidences of synergy were found for both antibiotic pairs tested on gentamicin-resistant isolates (Ps. aeruginosa and Providencia). In vitro findings suggest that piperacillin alone or in combination with aminoglycosides may be highly efficacious in the treatment of most serious bacterial infections.
