1980 年 33 巻 11 号 p. 1309-1315
The antibacterial activity of acyl derivatives of tylosin were examined in vitro and in vitro. The 4''-acyl group in the acylated tylosins enhanced the antibacterial activity and antimycoplasmal activity against some macrolide-resistant strains. The orally administered 3-acetyl-4''-isovaleryltylosin produced a higher blood level in mice and rabbits than tylosin and a good therapeutic effect on the infection of Staphylococcus aureus Smith in mice.