STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XXIV LEUSERAMYCIN, A NEW POLYETHER ANTIBIOTIC PRODUCED BY <i>STREPTOMYCES HYGROSCOPICUS</i>

TAKU MIZUTANI; MICHIO YAMAGISHI; HIROSHI HARA; AKIRA KAWASHIMA; SADAFUMI OMURA; MASAHIRO OZEKI

doi:10.7164/antibiotics.33.137

STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XXIV

LEUSERAMYCIN, A NEW POLYETHER ANTIBIOTIC PRODUCED BY STREPTOMYCES HYGROSCOPICUS

TAKU MIZUTANI, MICHIO YAMAGISHI, HIROSHI HARA, AKIRA KAWASHIMA, SADAFUMI OMURA, MASAHIRO OZEKI

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ジャーナルフリー

1980 年 33 巻 2 号 p. 137-143

DOI https://doi.org/10.7164/antibiotics.33.137

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抄録

A new antibiotic leuseramycin has been isolated from the cultured mycelium of the strain of Streptomyces hygroscopicus TM-531. Physicochemical data, in particular those of ¹H- and ¹³C-NMR spectra, revealed that leuseramycin is closely related to dianemycin in its structure, the former having a methyl group in place of the hydroxymethyl group at C-30. It is active against Gram-positive bacteria, some phytopathogenic fungi and some protozoa.

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