THIELAVIN A AND B, NEW INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS PRODUCED BY THIELAVIA TERRICOLA

抄録

Two potent inhibitors of prostaglandin biosynthesis, thielavin A (C₃₁H₃₄O₁₀) and B(C₂₉H₃₀O₁₀), were isolated from cultures of Thielavia terricola. Both of these compounds were shown to be structurally related to depsides, thus consisting of three hydroxybenzoic acid groups. Concentrations required for 50% inhibition of the conversion of ¹⁴C-arachidonic acid into prostaglandins F_2α, plus E₂ by microsomes of ram seminal vesicles were 12 μM for thielavin A and 9 μM for thielavin B, respectively. Of the enzymatic steps involved in prostaglandin synthesis, thielavin A specifically inhibited the conversion of arachidonic acid into prostaglandin H₂, while prostaglandin E₂ synthesis from the endoperoxide was the most sensitive to thielavin B.