KIJANIMICIN (Sch 25663), A NOVEL ANTIBIOTIC PRODUCED BY ACTINOMAD URA KIJANIATA SCC 1256 FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

J. ALLAN WAITZ; ANN C. HORAN; MANOHAR KALYANPUR; BONG K. LEE; DAVID LOEBENBERG; JOSEPH A. MARQUEZ; GEORGE MILLER; MAHESH G. PATEL

doi:10.7164/antibiotics.34.1101

KIJANIMICIN (Sch 25663), A NOVEL ANTIBIOTIC PRODUCED BY ACTINOMAD URA KIJANIATA SCC 1256

FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

J. ALLAN WAITZ, ANN C. HORAN, MANOHAR KALYANPUR, BONG K. LEE, DAVID LOEBENBERG, JOSEPH A. MARQUEZ, GEORGE MILLER, MAHESH G. PATEL

著者情報

ジャーナルフリー

1981 年 34 巻 9 号 p. 1101-1106

DOI https://doi.org/10.7164/antibiotics.34.1101

詳細

抄録

A novel antibiotic complex has been isolated from the fermentation broth of a new species of Actinomadura, A. kijaniata SCC 1256. The complex was separated from the broth by a solvent extraction procedure and consists of 1 major component, designated kijanimicin, and 3 minor components. Kijanimicin was isolated from the complex by column chromatography and/or preparative high pressure liquid chromatography. Structurally the compound is a unique, large acid enol antibiotic and possesses an unusual in vitro spectrum of activity against some Gram-positive and anaerobic microorganisms. In vivo it has also shown interesting activity against malaria.

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