METABOLIC PRODUCTS OF MICROORGANISMS. 200 ISOLATION AND CHARACTERIZATION OF NIPHITHRICINS A, B, AND ELAIOPHYLIN, ANTIBIOTICS PRODUCED BY <i>STREPTOMYCES VIOLACEONIGER</i>

H.-P. FIEDLER; W. WÖRNER; H. ZÄHNER; H. P. KAISER; W. KELLER-SCHIERLEIN; A. MÜLLER

doi:10.7164/antibiotics.34.1107

METABOLIC PRODUCTS OF MICROORGANISMS. 200

ISOLATION AND CHARACTERIZATION OF NIPHITHRICINS A, B, AND ELAIOPHYLIN, ANTIBIOTICS PRODUCED BY STREPTOMYCES VIOLACEONIGER

H.-P. FIEDLER, W. WÖRNER, H. ZÄHNER, H. P. KAISER, W. KELLER-SCHIERLEIN, A. MÜLLER

著者情報

ジャーナルフリー

1981 年 34 巻 9 号 p. 1107-1118

DOI https://doi.org/10.7164/antibiotics.34.1107

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抄録

Fermentations of Streptomyces violaceoniger TÜ 905 produce the antifungal antibiotics niphithricins A, B, elaiophylin and nigericin. The niphithricins have been characterized as new macrolide antibiotics, and the previously unknown structure of elaiophylin was determined to be a macrodiolide. The niphithricins were biologically active against Gram-positive bacteria and fungi. The mode of action is attributed to an alteration of the membrane permeability.

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