The efficiency in inducing cation permeability of vacidin A, candicidin D and amphotericin B has been compared on small and large lipidic vesicles. Amphotericin B is two times less effective on large than on small vesicles, On the contrary, vacidin A and candicidin D are about ten times more effective on large than on small vesicles. These data are consonant with what js observed on living cells.
