SYNTHETIC CEPHALOSPORINS

THE SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF 7-[2-(2-(AMINO-1, 3, 4-THIADIAZOL-5-YL)ACETAMIDO]-CEPHALOSPORINS

抄録

Synthesis and antibacterial activities of 7-[2-(2-amino-1, 3, 4-thiadiazol-5-yl)acetamido]-cephalosporins and their derivatives having the methoxyimino group at the 2-position of the 7-acyl moiety are described. These compounds are of interest as structural analogues of potent antibiotics, 7-[2-(2-aminothiazol-4-yl)acetamido]cephalosporins. 7-[2-(2-Amino-1, 3, 4-thiadi-azol-5-yl)acetamido]cephalosporins showed comparable activity with cefazolin. Introduction of methoxyimino group to the 7-side chain resulted in a lowering of activity.