14-ESTERS OF 7-O-(3, 4-DI-O-ACETYL-2, 6-DIDEOXY-α-L-LYXO-HEXOPYRANOSYL)ADRIAMYCINONE: SYNTHESIS AND ANTITUMOR ACTIVITY

抄録

A range of 14-esters (8-13) of the title compound, 3'-deamino-3'-hydroxydoxorubicin 3', 4'-diacetate (5), has been synthesized by nucleophilic substitution of the corresponding 14-bromide (6) by the appropriate sodium carboxylate salts. Antitumor activities were determined in vivo in the murine P388 lymphocytic leukemia assay and compared with those of the 14-hydroxy and 14-acetoxy analogs.