STUDIES ON NEW ANTIPLATELET AGENTS, WS-30581 A AND B

KAZUYOSHI UMEHARA; KEIZO YOSHIDA; MASANORI OKAMOTO; MORITA IWAMI; HIROKAZU TANAKA; MASANOBU KOHSAKA; HIROSHI IMANAKA

doi:10.7164/antibiotics.37.1153

KAZUYOSHI UMEHARA, KEIZO YOSHIDA, MASANORI OKAMOTO, MORITA IWAMI, HIROKAZU TANAKA, MASANOBU KOHSAKA, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 10 Pages 1153-1160

DOI https://doi.org/10.7164/antibiotics.37.1153

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Abstract

WS-30581 A and B are antiplatelet agents produced by a strain of Streptoverticillium waksmanii. The compounds were purified by solvent extraction and column chromatography, and identified as new pimprinine analogs on the basis of their physico-chemical properties. The producing organism produced pimprinine along with these compounds. Pimprinine and the two new analogs have potent inhibitory effects on platelet aggregation.

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