LAVENDOMYCIN, A NEW ANTIBIOTIC

I. TAXONOMY, ISOLATION AND CHARACTERIZATION

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Lavendomycin, a new basic peptide antibiotic containing novel amino acids, has been isolated from the culture broth of a streptomyces designated as Streptomyces lavendulae subsp. brasilicus. The antibiotic obtained as colorless crystals (C₂₉H₅₀N₁₀O₈, MW 666) is active against Gram-positive bacteria in vitro and in vivo, however, inactive against Gramnegative bacteria and fungi. An acute toxicity of the antibiotic in mice was LD₅₀>2 g/kg by subcutaneous injection.