STUDIES ON A NOVEL CYTOCIDAL ANTIBIOTIC, TRIENOMYCIN A

TAXONOMY, FERMENTATION, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS

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A new antibiotic, trienomycin A, has been isolated from the culture broth of Streptomyces sp. No. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C₃₆H₅₀N₃O₇( MW 622). The antibiotic possesses potent cytocidal activity against HeLa S₃ and PLC hepatoma cells at concentrations of 0.1 and 0.01 μg/ml (IC₅₀ value) respectively. However, trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1, 000 μg/ml.