TWO NEW INHIBITORS OF PHOSPHOLIPASE A2 PRODUCED BY PENICILLIUM CHERMESINUM TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

PUSHPA D. SINGH; JANICE H. JOHNSON; CAROL A. AKLONIS; KAREN BUSH; SUSAN M. FISHER; JOSEPH O'SULLIVAN

doi:10.7164/antibiotics.38.706

TWO NEW INHIBITORS OF PHOSPHOLIPASE A₂ PRODUCED BY PENICILLIUM CHERMESINUM

TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

PUSHPA D. SINGH, JANICE H. JOHNSON, CAROL A. AKLONIS, KAREN BUSH, SUSAN M. FISHER, JOSEPH O'SULLIVAN

著者情報

ジャーナルフリー

1985 年 38 巻 6 号 p. 706-712

DOI https://doi.org/10.7164/antibiotics.38.706

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抄録

Plastatin and the known fungal metabolite, luteosporin, have been isolated from fermentations of Penicillium chermesinum as inhibitors of porcine pancreatic phospholipase A₂ (PLA₂). Structure 1 for plastatin was deduced from its spectroscopic properties. Plastatin and luteosporin inhibited pancreatic PLA₂ competitively with Ki values of 0.89 μM and 12.8 μM, respectively. PLA₂ preparations from Naja naja and Crotalus adamanteus were not significantly inhibited by plastatin and luteosporin.

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