AMINOGLYCOSIDE ANTIBIOTICS 7. DIHYDROSTREPTOMYCIN ANALOGUES

DANA L. DELAWARE; MAHENDRA S. SHARMA; BHASHYAM S. IYENGAR; WILLIAM A. REMERS; TERESA A. PURSIANO

doi:10.7164/antibiotics.39.251

AMINOGLYCOSIDE ANTIBIOTICS

7. DIHYDROSTREPTOMYCIN ANALOGUES

DANA L. DELAWARE, MAHENDRA S. SHARMA, BHASHYAM S. IYENGAR, WILLIAM A. REMERS, TERESA A. PURSIANO

著者情報

ジャーナルフリー

1986 年 39 巻 2 号 p. 251-258

DOI https://doi.org/10.7164/antibiotics.39.251

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抄録

Dihydrostreptomycin analogues with structural variations in their guanidino groups were prepared. The analogue with a methyl group on the guanidine at C-1 was nearly as active as dihydrostreptomycin against bacteria. However, the 2-imidazolin-2-ylamino substituent at C-1 eliminated activity. No analogue with a substituent on the C-3 guanidino group was active.

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