BIOSYNTHESIS OF FLUOROTHREONINE AND FLUOROACETIC ACID BY THE THIENAMYCIN PRODUCER, <i>STREPTOMYCES CATTLEYA</i>

MINORU SANADA; TETSUJI MIYANO; SHUICHI IWADARE; JOANNE M. WILLIAMSON; BYRON H. ARISON; JACK L. SMITH; ALAN W. DOUGLAS; JERROLD M. LIESCH; EDWARD INAMINE

doi:10.7164/antibiotics.39.259

BIOSYNTHESIS OF FLUOROTHREONINE AND FLUOROACETIC

ACID BY THE THIENAMYCIN PRODUCER, STREPTOMYCES CATTLEYA

MINORU SANADA, TETSUJI MIYANO, SHUICHI IWADARE, JOANNE M. WILLIAMSON, BYRON H. ARISON, JACK L. SMITH, ALAN W. DOUGLAS, JERROLD M. LIESCH, EDWARD INAMINE

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ジャーナルフリー

1986 年 39 巻 2 号 p. 259-265

DOI https://doi.org/10.7164/antibiotics.39.259

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抄録

An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate. THX was subsequently identified as one of the four possible stereoisomers of 4-fluorothreonine. Inorganic fluoride or any one of a number of organofluorine compounds can be used as precursors of 4-fluorothreonine. In addition, ¹⁹F NMR has provided evidence that the organism synthesizes fluoroacetate under the same fermentation conditions. The in vitro antibacterial spectrum of 4-fluorothreonine is also presented.

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