NEW TYLOSIN ANALOGS PRODUCED BY MUTANTS OF STREPTOMYCES FRADIAE

KOHKI KIYOSHIMA; KAZUAKI TAKADA; MASAO YAMAMOTO; KATSURO KUBO; ROKURO OKAMOTO; YASUO FUKAGAWA; TOMOYUKI ISHIKURA; HIROSHI NAGANAWA; TSUTOMU SAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.40.1123

NEW TYLOSIN ANALOGS PRODUCED BY MUTANTS OF STREPTOMYCES FRADIAE

KOHKI KIYOSHIMA, KAZUAKI TAKADA, MASAO YAMAMOTO, KATSURO KUBO, ROKURO OKAMOTO, YASUO FUKAGAWA, TOMOYUKI ISHIKURA, HIROSHI NAGANAWA, TSUTOMU SAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA

著者情報

ジャーナルフリー

1987 年 40 巻 8 号 p. 1123-1130

DOI https://doi.org/10.7164/antibiotics.40.1123

詳細

抄録

2'''-Demethoxytylosin (component IIIc), 2'''-demethoxy-4'''-epi-tylosin (component IIId) and 2'''-O-demethyltylosin (component Vb) were produced by blocked mutant strains of Streptomyces fradiae. Fermentation, isolation, structure determination and biosynthetic considerations of these tylosin analogs are described.

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