LL-F28249 ANTIBIOTIC COMPLEX: A NEW FAMILY OF ANTIPARASITIC MACROCYCLIC LACTONES ISOLATION, CHARACTERIZATION AND STRUCTURES OF LL-F28249 α, β, γ, λ

GUY T. CARTER; JEANNE A. NIETSCHE; MARTIN R. HERTZ; DAVID R. WILLIAMS; MARSHALL M. SIEGEL; GEORGE O. MORTON; JOHN C. JAMES; DONALD B. BORDERS

doi:10.7164/antibiotics.41.519

LL-F28249 ANTIBIOTIC COMPLEX: A NEW FAMILY OF ANTIPARASITIC MACROCYCLIC LACTONES

ISOLATION, CHARACTERIZATION AND STRUCTURES OF LL-F28249 α, β, γ, λ

GUY T. CARTER, JEANNE A. NIETSCHE, MARTIN R. HERTZ, DAVID R. WILLIAMS, MARSHALL M. SIEGEL, GEORGE O. MORTON, JOHN C. JAMES, DONALD B. BORDERS

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JOURNAL FREE ACCESS

1988 Volume 41 Issue 4 Pages 519-529

DOI https://doi.org/10.7164/antibiotics.41.519

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Abstract

A new family of antiparasitic macrolides has been isolated from Streptomyces cyaneogriseus sp. noncyanogenus. The compounds, designated LL-F28249 α, β, γ and λ, possess potent antiparasitic activity. The isolation, purification and structure determination by spectroscopic methods are presented.

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