The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PROBESTIN, A NEW INHIBITOR OF AMINOPEPTIDASE M, PRODUCED BY STREPTOMYCES AZUREUS MH663-2F6
I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
TAKAAKI AOYAGI, SHIGEMI YOSHIDA, YASUSHI NAKAMURA, YASUHIRO SHIGIHARA, MASA HAMADA, TOMIO TAKEUCHI
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1990 年 43 巻 2 号 p. 143-148

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Probestin has been isolated as part of a program designed to find microorganism-produced inhibitors of aminopeptidase M from Streptomyces azureus MH663-2F6. It was purified by use of column chromatography of Amberlite XAD-4, silica gel, YMC-gel, Toyopearl HW-40, YMC D-ODS-5 (HPLC) and then isolated as colorless powders. Probestin is competitive with the substrate, and the inhibition constant (Ki) of it was 1.9×10-8 M.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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