The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SPERABILLINS, NEW ANTIBACTERIAL ANTIBIOTICS WITH POTENT IN VIVO ACTIVITY
TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY
NOZOMI KATAYAMAYUKIMASA NOZAKISHIGETOSHI TSUBOTANIMASAHIRO KONDOSETSUO HARADAHIDEO ONO
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1992 Volume 45 Issue 1 Pages 10-19

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Abstract

A Gram-negative bacterium was found to produce new antibacterial antibiotics, sperabillins A, B, C and D, and the producing bacterium was characterized and identified as Pseudomonas fluorescens YK-437. Sperabillins were isolated by column chromatographies using cation-exchange resins, activated carbon and cation-exchange Sephadex, and preparative reverse-phase HPLC. Sperabillins showed antibacterial activity against Gram-negative and Gram-positive bacteria including antibiotic-resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Sperabillin A inhibited DNA, RNA, protein, and cell wall biosynthesis in Escherichia coli. Sperabillins showed good protective effects in experimentally infected mice.

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© Japan Antibiotics Research Association
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