WS-7338, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 7338 II. BIOLOGICAL CHARACTERIZATION AND PHARMACOLOGICAL CHARACTERIZATION OF WS-7338 B

SUSUMU MIYATA; MICHIZANE HASHIMOTO; KEIKO FUJIE; MOTOAKI NISHIKAWA; SUMIO KIYOTO; MASAKUNI OKUHARA; MASANOBU KOHSAKA

doi:10.7164/antibiotics.45.83

WS-7338, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 7338

II. BIOLOGICAL CHARACTERIZATION AND PHARMACOLOGICAL CHARACTERIZATION OF WS-7338 B

SUSUMU MIYATA, MICHIZANE HASHIMOTO, KEIKO FUJIE, MOTOAKI NISHIKAWA, SUMIO KIYOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 1 Pages 83-87

DOI https://doi.org/10.7164/antibiotics.45.83

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Abstract

WS-7338, produced by Streptomyces sp. No. 7338, was found to be a competitive and specific antagonist against ET-1 receptors in in vitro studies and WS-7338 B is also active in vivo. Furthermore, WS-7338 B was a specific antagonist for vascular ET-1 receptors (ET_A receptors) and significantly prevented the accumulation of intracellular inositol 1, 4, 5-triphosphate (IP₃) in endothelin treated rat aorta tissues.

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